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Myelofibrosis
Momelotinib, a Novel JAK Inhibitor, Makes Inroads in Intermediate- or High-Risk Myelofibrosis
By
Phoebe Starr
Myelofibrosis
February 2021, Vol 12, No 1
Momelotinib, a selective and orally bioavailable inhibitor of Janus kinase (
JAK
)
1
,
JAK2
, and
ACVR1
, improved overall survival and sustained efficacy outcomes in patients with intermediate- or high-risk myelofibrosis, according to updated findings from the phase 3 SIMPLIFY-1 and SIMPLIFY-2 clinical trials presented at ASH 2020. Momelotinib was of benefit to patients who previously received treatment with ruxolitinib (Jakafi) and those who had not received a
JAK
inhibitor.
Read Article
Investigational BET Inhibitor, CPI-0610, Promotes Responses in Myelofibrosis
By
Wayne Kuznar
Myelofibrosis
February 2020, Vol 11, No 1 | Payers’ Perspectives In Oncology | Including ASH 2019 Highlights
Orlando, FL—A potent, oral small-molecule bromodomain and extraterminal domain (BET) inhibitor—CPI-0610—improves spleen volume and symptoms when added to the Janus kinase (JAK) inhibitor ruxolitinib (Jakafi) in ruxolitinib-naïve patients with myelofibrosis. Ruxolitinib is the only FDA-approved treatment for myelofibrosis.
Read Article
Pacritinib Shows Good Efficacy in Myelofibrosis: Will the FDA Release Hold on the Drug?
By
Phoebe Starr
Myelofibrosis
February 2017, Vol 8, No 1
San Diego, CA—The investigational drug pacritinib, a JAK1/JAK2 inhibitor, achieved benefits in patients with myelofibrosis, including a significant reduction in the spleen volume compared with the best available therapy that included the JAK1/JAK2 inhibitor ruxolitinib (Jakafi), according to the phase 3 PERSIST-2 clinical trial. The results were presented by John O. Mascarenhas, MD, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, at the 2016 American Society of Hematology (ASH) meeting.
Read Article
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Home
Issues
Online First
Latest Issue
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Personalized Medicine
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Conference Correspondent
SABCS 2023 - HER2+ MBC
ASCO 2023 - Breast Cancer
Web Exclusives
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Interview with the Innovators
Prostate Cancer Diagnostics Monthly Minutes
Webinars
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AVBCC
Association for Value-Based Cancer Care
VBCM
Value-Based Care in Myeloma