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Molecular Signature for Neuroendocrine Prostate Cancer Represents Progress
By
Alice Goodman
Personalized Medicine
,
Prostate Cancer
,
Solid Tumors
September 2015, Vol 6, No 8
Boston, MA—Researchers have defined an 81-feature molecular signature to identify neuroendocrine prostate cancer (NEPC), an aggressive and rapidly progressing entity that is increasingly being recognized in patients with advanced disease and signals poor overall survival. The signature, derived from genomic, transcription, and methylation analysis, relies heavily on epigenetic alterations.
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Enzalutamide Outperforms Bicalutamide in 2 Trials of Prostate Cancer
By
Wayne Kuznar
Prostate Cancer
,
Solid Tumors
September 2015, Vol 6, No 8
Enzalutamide (Xtandi) outperformed bicalutamide (Casodex) in separate phase 2 clinical trials of men with prostate cancer, according to data presented at the 2015 American Urological Association annual meeting.
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Cell Surface Amino Acid Potential as Prostate Cancer Biomarker
By
Wayne Kuznar
Personalized Medicine
,
Prostate Cancer
,
Solid Tumors
August 2015, Vol 6, No 7
New Orleans, LA—Prostate cancer may soon have a new biomarker. The cell surface amino acid glypican-1 (GPC-1) was shown in a pilot study to have specificity of 70% for prostate cancer with a sensitivity of >30%, said Jonathan Henderson, MD, a urologist at Regional Urology in Shreveport, LA, at the 2015 American Urological Association meeting.
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More Bad News for Erythropoiesis-Stimulating Agents in Chemotherapy-Induced Anemia
By
Charles Bankhead
Breast Cancer
,
Solid Tumors
March 2015, Vol 6, No 2
San Antonio, TX—Adding an erythropoiesis-stimulating agent (ESA) to best supportive care failed to demonstrate noninferiority for progression-free survival (PFS) compared with best supportive care alone in patients with metastatic breast cancer, in a clinical trial known as EPO-ANE-3010 that was requested by the FDA.
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Lowering Dietary Fat Increases Long-Term Survival in Women with Hormone-Negative Breast Cancer
By
Alice Goodman
Breast Cancer
,
Solid Tumors
March 2015, Vol 6, No 2
San Antonio, TX—Results of a new nutrition study show that women who reduced their intake of dietary fat for 5 years after being diagnosed with early breast cancer had significantly lower rates of death from all causes compared with controls, at 15 years of follow-up; this reduction was seen specifically in women with hormone receptor (HR)-negative breast cancer. No long-term effect of dietary fat reduction on mortality was observed in women with HR-positive breast cancer. The results of the study, called Women’s Intervention Nutrition Study (WINS), were presented at the 2014 San Antonio Breast Cancer Symposium.
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Debate on PSA Prostate Cancer Screening Redux
By
Phoebe Starr
Genitourinary Cancers Symposium
,
Prostate Cancer
,
Solid Tumors
March 2015, Vol 6, No 2
Orlando, FL—A new retrospective study of 87,562 men diagnosed with prostate cancer between January 2005 and June 2013 show that the incidence of prostate cancer and men with prostate-specific antigen (PSA) >10 decreased gradually between 2005 and 2011. However, the incidence of high-risk prostate cancer at diagnosis increased annually by 3% between 2011 and 2013, totaling 6%. This increase could lead to an additional 1400 prostate cancer deaths 10 years later.
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AR-V7 Predicts Chemotherapy Sensitivity in Metastatic Prostate Cancer
By
Phoebe Starr
Personalized Medicine
,
Prostate Cancer
,
Solid Tumors
March 2015, Vol 6, No 2
Orlando, FL—Experts are hopeful that the field of prostate cancer will soon be catching up to breast cancer and some other tumor types with regard to genomic markers. A study featured at the 2015 Genitourinary Cancers Symposium suggests that the androgen receptor (AR) abnormality known as “AR-V7” will turn out to be a predictive marker to help in treatment selection for patients with metastatic castration-resistant prostate cancer (CRPC).
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Postresection Routine Surveillance with CT Instead of Chest X-Ray Does Not Improve Survival in Early-Stage Lung Cancer
By
Rosemary Frei, MSc
Lung Cancer
,
Solid Tumors
October 2014, Vol 5 , No 8
Toronto, Canada—Survival is not improved with routine surveillance using computed tomography (CT) versus chest x-ray in patients who have undergone resection for stage I non–small-cell lung cancer (NSCLC), according to the results of a new analysis presented at the 2014 American Association for Thoracic Surgery meeting.
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Comparing the Safety and Efficacy of Stereotactic Radiotherapy versus Surgery in Lung Cancer
By
Laura Morgan
Lung Cancer
,
Solid Tumors
October 2014, Vol 5 , No 8
San Francisco, CA—The use of stereotactic body radiotherapy (SBRT), also called stereotactic radiotherapy or radiosurgery, is an effective option for elderly patients with cancer who are inoperable or who decline surgery, but its safety and efficacy compared with surgery have not been investigated.
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Study Identifies Important Benefits of Cancer Survivorship Programs
By
Charles Bankhead
Breast Cancer
,
Solid Tumors
October 2014, Vol 5 , No 8
San Francisco, CA—Patients with breast cancer who attended survivorship clinics demonstrated improved compliance with follow-up visits, increased use of supportive services, and felt their concerns were better addressed, according to the results of a cancer center’s patient survey reported by Leah L. Dietrich, MD, an oncologist at Gundersen Health System, La Crosse, WI, at the 2014 Breast Cancer Symposium.
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Home
Issues
Online First
Latest Issue
Issue Archive
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Browse By Topic
Personalized Medicine
Economics & Value
FDA Approvals, News & Updates
COVID-19
Cholangiocarcinoma
View All Topics ›
Conference Correspondent
SABCS 2023 - HER2+ MBC
ASCO 2023 - Breast Cancer
Web Exclusives
Web Exclusive Articles
Videos
Interview with the Innovators
Prostate Cancer Diagnostics Monthly Minutes
Webinars
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AVBCC
Association for Value-Based Cancer Care
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Value-Based Care in Myeloma