September 2015, Vol 6, No 8

Boston, MA—Rociletinib, a specially engineered third-generation EGFR inhibitor, is accumulating an impressive track record in early studies of non–small-cell lung cancer (NSCLC). The drug is specifically designed for use in patients with NSCLC and the T790M mutation, a heretofore patient population with unmet needs. T790M, the most common mutation associated with resistance to first-line EGFR-directed tyrosine kinase inhibitor (TKI) therapy, is present in 60% of patients with resistance to TKIs.
Read Article

Boston, MA—Researchers have defined an 81-feature molecular signature to identify neuroendocrine prostate cancer (NEPC), an aggressive and rapidly progressing entity that is increasingly being recognized in patients with advanced disease and signals poor overall survival. The signature, derived from genomic, transcription, and methylation analysis, relies heavily on epigenetic alterations.
Read Article



I believe that the dialogue and thoughts being shared and expressed by all cancer care stakeholders is exactly what we need today. Frankly, the conversation has been underground far too long, but the headlines today have been focused solely on the drug cost. Anyone thinking that cancer care costs are going to go down, simply doesn’t understand healthcare economics, because the cost to society will continue to go up over time, with true innovation and value delivered.
Read Article

TMed will improve the selection of treatments by adding back and analyzing all the relevant data about the variability of response and the multiplicity of causes…from thousands, if not millions, of patients.
Read Article

Clinicians will soon have more targeted therapies at their disposal, including drugs with novel mechanisms of action.
Read Article

Enzalutamide (Xtandi) outperformed bicalutamide (Casodex) in separate phase 2 clinical trials of men with prostate cancer, according to data presented at the 2015 American Urological Association annual meeting.
Read Article

The definition of value by patients with cancer does not necessarily coincide with other definitions by other stakeholders.
Read Article

Page 2 of 2