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Prostate Cancer

FDA Approves First Prostate-Specific Membrane Antigen–Targeted PET Imaging Drug for Prostate Cancer
FDA Approvals, News & Updates, Prostate Cancer
December 2020, Vol 11, No 6
On December 1, 2020, the FDA approved Gallium 68 PSMA-11 (Ga 68 PSMA-11; University of California), the first drug for positron emission tomography (PET) imaging of prostate-specific membrane antigen (PSMA)-positive lesions in men with prostate cancer. Ga 68 PSMA-11 is indicated for men with suspected metastatic prostate cancer that may be curable by surgery or by radiation, and for suspected recurrent prostate cancer based on elevated serum prostate-specific antigen (PSA) levels.
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Oral Relugolix Equals Standard ADT, Slashes Cardiac Events in Patients with Advanced Prostate Cancer
By Phoebe Starr
Prostate Cancer
August 2020, Vol 11, Special Issue: Payers' Perspectives in Oncology
Oral relugolix given daily is superior to standard androgen-­deprivation therapy (ADT) with leuprolide (Lupron) in men with advanced prostate cancer, according to the results of the phase 3 HERO study, which were reported at the ASCO 2020 virtual annual meeting and published online before the meeting.
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Cabozantinib plus Atezolizumab Combination Shows Meaningful Activity in Metastatic Prostate Cancer
By Phoebe Starr
Prostate Cancer
August 2020, Vol 11, Special Issue: Payers' Perspectives in Oncology
The combination of cabozantinib (Cabometyx), a kinase inhibitor, and atezolizumab (Tecentriq), a PD-L1 inhibitor, achieved clinically meaningful activity in patients with metastatic castration-resistant prostate cancer (CRPC), including those with high-risk clinical features, according to the results of the phase 1b COSMIC-021 trial presented at the ASCO 2020 virtual annual meeting.
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Early Phase 2 Data Promising for Lutetium-177 PSMA-617 in Metastatic Prostate Cancer
By Phoebe Starr
Prostate Cancer
August 2020, Vol 11, Special Issue: Payers' Perspectives in Oncology
Early results from the phase 2 TheraP clinical trial show that the targeted radiation therapy Lutetium-177 PSMA-617 (Lu-PSMA) significantly improved prostate-specific antigen (PSA) response compared with standard cabazitaxel in men with metastatic castration-resistant prostate cancer (CRPC) that progressed after docetaxel therapy.
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Immune Checkpoint Inhibitor Does Not Improve Outcomes in Metastatic Prostate Cancer
By Phoebe Starr
Prostate Cancer
June 2020, Vol 11, No 3
No improvement in survival or in any key secondary end point was observed when the checkpoint inhibitor atezolizumab (Tecentriq) was added to enzalutamide (Xtandi) for the treatment of metastatic castration-resistant prostate cancer (CRPC) in the phase 3 IMbassador250 trial. The study results were presented at the 2020 American Association for Cancer Research virtual annual meeting.
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Androgen-Deprivation Therapy Seldom Used with Radiation in Localized Prostate Cancer
By Wayne Kuznar
Prostate Cancer
June 2020, Vol 11, No 3
San Francisco, CA—Today, patients who receive stereotactic body radiation therapy (SBRT) for intermediate- or high-risk localized prostate cancer are not receiving concurrent androgen-deprivation therapy (ADT), despite national guideline recommendations that support the concurrent use of ADT with radiation therapy.
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Lynparza Approved for Metastatic Prostate Cancer with HRR Mutation
FDA Approvals, News & Updates, Prostate Cancer
Web Exclusives
On May 19, 2020, the FDA approved a new indication for olaparib (Lynparza; AstraZeneca), a PARP inhibitor, for the treatment of men with metastatic castration-resistant prostate cancer and deleterious or suspected deleterious germline or somatic HRR mutation, as determined by an FDA-approved test, whose disease progressed after enzalutamide (Xtandi) or abiraterone acetate (Zytiga) therapy. Olaparib is the first FDA-approved PARP inhibitor for prostate cancer.
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PSMA-PET Scanning Wave of the Future in Prostate Cancer
By Phoebe Starr
Prostate Cancer
April 2020, Vol 11, No 2

San Francisco, CA—Positron emission tomography (PET) scanning targeted to detect prostate-specific membrane antigen (PSMA) is poised to overtake conventional imaging, according to presentations at the 2020 Genitourinary Cancers Symposium.

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Cabozantinib–Atezolizumab Combination Shows Activity in Difficult-to-Treat Prostate Cancer
By Wayne Kuznar
Prostate Cancer
April 2020, Vol 11, No 2

San Francisco, CA—Combining cabozantinib (Cabometyx) with atezolizumab (Tecentriq) induced responses in 32% of patients with metastatic castration- resistant prostate cancer (CRPC) who had soft-tissue progression after previous novel hormonal therapy.

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