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AACR Annual Meeting
FGFR Inhibitor Shows Promising Anticancer Activity
By
Phoebe Starr
AACR Annual Meeting
May 2014, Vol 5, No 4
San Diego, CA—Inhibition of fibroblast growth factor receptors (FGFRs) 1, 2, 3, and 4 is showing promise in the treatment of cancers driven by FGFR alterations, especially bladder cancer and lung cancer, according to phase 1 studies presented at the 2014 American Association for Cancer Research annual meeting.
Read Article
Multitargeted Kinase Inhibitor Shows Promise for Breast Cancer Subgroup
By
Charles Bankhead
AACR Annual Meeting
May 2014, Vol 5, No 4
San Diego, CA—A multitargeted kinase inhibitor met criteria for a phase 3 clinical trial in breast cancer after statistical modeling of clinical data showed a high probability of success versus standard therapy for patients with HER2-positive/hormone receptor (HR)-negative (HER2+/HR–) disease.
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Highest Response in Metastatic Renal-Cell Carcinoma with Pazopanib, Third-Line VEGF Inhibitor
By
Charles Bankhead
AACR Annual Meeting
May 2014, Vol 5, No 4
San Diego, CA—Almost 50% of patients with metastatic renal-cell carcinoma (mRCC) had objective responses to third-line treatment with the angiogenesis inhibitor pazopanib, according to the results of a small clinical trial reported at the 2014 American Association for Cancer Research annual meeting.
Read Article
Potential New Approach to Melanoma
By
Phoebe Starr
AACR Annual Meeting
May 2014, Vol 5, No 4
San Diego, CA—Preliminary results suggest that an investigational antibody-drug conjugate called DEDN-6526A (Seattle Genetics, Genentech) has activity against melanoma, including cutaneous, mucosal, and ocular melanoma, which is considered difficult to treat. The new drug comes on the heels of trastuzumab emtansine, the first antibody-drug conjugate approved by the US Food and Drug Administration for the treatment of breast cancer.
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AG-221 Achieved Excellent Responses in Relapsed, Refractory Leukemia, Myelodysplastic Syndrome
By
Phoebe Starr
AACR Annual Meeting
May 2014, Vol 5, No 4
San Diego, CA—Preliminary data suggest that a novel agent called AG-221 can induce complete remissions (CRs) in patients with relapsed, refractory acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) who harbor mutated
IDH2
. These exciting results were achieved in patients with an ominous prognosis who have few or no other treatment options. The data were presented at the 2014 American Association for Cancer Research (AACR) annual meeting.
Read Article
CDK 4/6 Inhibitor Slows Progression of Metastatic Breast Cancer
By
Charles Bankhead
AACR Annual Meeting
May 2014, Vol 5, No 4
San Diego, CA—Palbociclib, an inhibitor of cyclin-dependent kinase (CDK) 4/6, demonstrated “striking” activity when combined with conventional hormone therapy for patients with metastatic breast cancer, according to the results of an open-label phase 2 trial presented at the 2014 American Association for Cancer Research annual meeting.
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Genetically Engineered T Cells for Childhood Leukemia
AACR Annual Meeting
May 2013, Vol 4, No 4
Read Article
Positron Emission Tomography Scanning May Identify Stage I NSCLC that Requires Chemotherapy
By
Charles Bankhead
AACR Annual Meeting
May 2013, Vol 4, No 4
Read Article
False-Positive Lung Cancer Rates Vary Widely by State
AACR Annual Meeting
May 2013, Vol 4, No 4
Lung cancer false- positive rates varied 20-fold across the United States, raising questions about the potential impact on organized screening programs, according to data presented at the 2013 American Association for Cancer Research annual meeting.
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New Mantle-Cell Regimen Leads to “Remarkable” Response Rate
By
Charles Bankhead
AACR Annual Meeting
May 2013, Vol 4, No 4
A chemotherapy–immunotherapy combination has been shown to be extremely effective in a small clinical trial of previously untreated mantle-cell lymphoma, leading to objective responses in every patient, including complete responses in almost 90%, investigators reported at the 2013 American Association for Cancer Research annual meeting.
Read Article
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