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Issues
2019
June 2019, Vol 10, No 3
June 2019, Vol 10, No 3
High Tumor Mutation Burden Predictive Biomarker for Survival in Metastatic Lung Cancer
By
Phoebe Starr
Lung Cancer
,
Solid Tumors
,
Personalized Medicine
June 2019, Vol 10, No 3
Atlanta, GA—Immune checkpoint inhibitors represent a tremendous advance in the treatment of several types of cancers. Although approximately 20% to 25% of patients will have durable responses with these agents, it has been challenging to find biomarkers to identify who these patients are.
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Call to Action: Greater Focus on Metastatic Cancer Survivors Is Needed
By
Eileen Koutnik-Fotopoulos
Metastatic Cancer
June 2019, Vol 10, No 3
Two cancer experts at Johns Hopkins Kimmel Cancer Center in Baltimore, MD, are advocating for greater focus on metastatic cancer survivorship and its impact on those living with incurable cancer, a situation they know all too well. Both are living with metastatic cancer and are urging the medical community to increase the study and awareness of this condition and improve the lives of this growing population.
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Expert Panel Discusses Access to CAR T-Cell Therapy
By
Wayne Kuznar
2019 NCCN Conference
June 2019, Vol 10, No 3
Orlando, FL—With price tags approaching $1 million or more for delivery of certain immune cell therapies, new payment models will be needed to ensure access to these therapies and to further innovations. This was a key issue addressed at a roundtable discussion at the 2019 National Comprehensive Cancer Network (NCCN) Conference. Ensuring access to chimeric antigen receptor (CAR) T-cell therapy emerged as a top area of concern.
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Evolving Immuno-Oncology Strategies in Renal-Cell Carcinoma
By
Wayne Kuznar
Immunotherapy
,
Renal-Cell Carcinoma
,
Personalized Medicine
June 2019, Vol 10, No 3
San Francisco, CA—The era of immunotherapy has opened new perspectives in renal-cell carcinoma (RCC), which is one of the tumors most highly infiltrated with CD T-cells and PD-1 expression, partially accounting for its sensitivity to immunotherapy. Other mechanisms to explain its sensitivity include myeloid infiltration, metabolic alterations, loss-of-function mutations, and human endogenous retroviruses.
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Durvalumab plus Tremelimumab Immunotherapy Combination Extends Survival in Refractory Colorectal Cancer
By
Wayne Kuznar
Immunotherapy
,
Personalized Medicine
June 2019, Vol 10, No 3
San Francisco, CA—The combination of the PD-1 inhibitor durvalumab (Imfinzi) and the investigational CTLA-4 inhibitor tremelimumab plus best supportive care improved overall survival (OS) by more than 2 months versus best supportive care alone in a phase 2 clinical trial of patients with refractory colorectal cancer (CRC), reported Eric Xueyu Chen, MD, PhD, Staff Oncologist, Princess Margaret Cancer Centre, Toronto, Canada, at the 2019 Gastrointestinal Cancers Symposium.
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Home
Issues
Online First
Latest Issue
Issue Archive
Special Issues
Browse By Topic
Personalized Medicine
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FDA Approvals, News & Updates
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Cholangiocarcinoma
View All Topics ›
Conference Correspondent
SABCS 2023 - HER2+ MBC
ASCO 2023 - Breast Cancer
Web Exclusives
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Prostate Cancer Diagnostics Monthly Minutes
Webinars
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Value-Based Care in Myeloma