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Cholangiocarcinoma
Supportive Care and Management of Complications in BTCs: A Multidisciplinary Team Approach
Cholangiocarcinoma
February 2023, Vol 14, No 1
At the 4th Annual Cholangiocarcinoma Summit, held on October 13-15, 2022, in Aurora, CO, experts in the field of gastroenterology, interventional radiology, nursing, and surgery discussed the importance of using a multidisciplinary approach to supportive care and the management of complications in patients with biliary tract cancers (BTCs).
Read Article
GemCis with or without CPI-613 as First-Line Therapy for Patients with Advanced BTCs: The BilT-04 Study
Cholangiocarcinoma
October 2022, Vol 13, No 5
Patients with advanced biliary tract cancers (BTCs) have a poor prognosis despite systemic chemotherapy.
Read Article
TOPAZ-1: Durvalumab plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer
Cholangiocarcinoma
June 2022, Vol 13, No 3
The global, double-blind, placebo-controlled, phase 3 TOPAZ-1 clinical trial evaluated the first-line chemoimmunotherapy regimen of the PD-L1 inhibitor durvalumab (Imfinzi) plus gemcitabine and cisplatin in patients with advanced biliary tract cancer.
Read Article
Family History of Primary Liver Cancer Associated with Increased Risk for Extrahepatic CCA
Cholangiocarcinoma
June 2022, Vol 13, No 3
The subtypes of cholangiocarcinoma (CCA), including intrahepatic CCA and extrahepatic CCA, have various underlying tumor microenvironments, pathobiology, epidemiologic features, and risk factors; however, the genetic underpinnings of the CCA subtypes have not been previously defined.
Read Article
The International Cholangiocarcinoma Research Network Program Initiatives
Cholangiocarcinoma
April 2022, Vol 13, No 2
The International Cholangiocarcinoma Research Network (ICRN) is a program initiated by the Cholangiocarcinoma Foundation (CCF).
Read Article
Role of Radiology in Intrahepatic Cholangiocarcinoma Addressed at the 2021 Interventional Oncology Meetings
Cholangiocarcinoma
October 2021, Vol 12, No 5
Key topics related to intrahepatic cholangiocarcinoma (CCA) were presented at the 2021 Society of Interventional Oncology (SIO) and the Society of Interventional Radiology (SIR) meetings and were discussed during the CCA Summit. Bruno C. Odisio, MD, FSIR, Interventional Radiologist and Co-Director of Research, Department of Interventional Radiology, M.D. Anderson Cancer Center, Houston, TX, reviewed the significance of these findings.
Read Article
Recent Developments in Genomic-Driven Therapies for Cholangiocarcinoma
Cholangiocarcinoma
,
Personalized Medicine
Web Exclusives
Personalized medicine has expanded the treatment options for patients with cholangiocarcinoma (CCA). At the 2021 Annual Meeting of the Cholangiocarcinoma Foundation (CCF), Ghassan K. Abou-Alfa, MD, MBA, Professor of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, discussed recent developments in personalized therapies, highlighting genomic alterations that are informing the new therapies for patients with CCA.
Read Article
Truseltiq Receives FDA Approval for the Treatment of Patients with Metastatic Cholangiocarcinoma Harboring FGFR2 Alterations
Cholangiocarcinoma
,
FDA Approvals, News & Updates
August 2021, Vol 12, No 4
On
May 28, 2021
, the FDA accelerated the approval of infigratinib (Truseltiq; QED Therapeutics), an oral kinase inhibitor, for the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma (CCA) and
FGFR2
fusion or other rearrangement, as detected by an FDA-approved test. The FDA granted infigratinib priority and fast-track review, as well as orphan drug designation for this indication.
Read Article
Truseltiq (Infigratinib) New Targeted Therapy FDA Approved for Advanced or Metastatic Cholangiocarcinoma Harboring FGFR2 Alterations
By
Loretta Fala
Cholangiocarcinoma
,
Drug Updates
August 2021, Vol 12, No 4
Cholangiocarcinoma (CCA) represents a group of heterogeneous cancers that originate in the bile ducts that connect the liver and gallbladder to the small intestine. Although the exact prevalence of CCA is unknown, CCA is a rare cancer; approximately 8000 new cases of CCA are diagnosed annually in the United States.
Read Article
Incorporating FGFR Inhibitors into the Treatment Paradigm for Cholangiocarcinoma: Current Concepts and Future Directions
By
Mitesh Borad, MD
;
Milind M. Javle, MD
;
Michael Morse, MD, FACP, MHS
;
Lewis R. Roberts, MB, ChB, PhD
Cholangiocarcinoma
,
Continuing Education
June 2021, Vol 12, No 3
On January 15, 2021, experts in the management of patients with cholangiocarcinoma (CCA) convened for a virtual accredited continuing education satellite symposium held during the 2021 annual meeting of the American Society of Clinical Oncology Gastrointestinal Cancers Symposium. The goal was to educate healthcare providers on various aspects of CCA, including epidemiology, current standards of care, unmet clinical needs, the safety and efficacy of fibroblast growth factor receptor (
FGFR
) inhibitors as second-line therapy, and practical approaches to incorporating
FGFR
inhibitors into the treatment paradigm for the disease.
Read Article
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